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In an obese group of subjects the half-life of alprazolam ranged between 9.9 and 40.4 hours (mean=21.8 hours, n=12) as compared to between 6.3 and 15.8 hours (mean=10.6 hours, n=12) in healthy subjects.
Both anorexia with some weight loss and increased appetite with weight gain have also been reported.
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This approach works well because bone marrow cells naturally develop into blood cells.
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Convulsions in children may be preceded by mild depression.
They build on submodels of biological and physiological systems and also exploit epidemiological models that take into account the local prevalence of diseases.
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Metformin is excreted unchanged in the urine.
One type found in the developing world, Shigella dysenteriae type 1, can cause deadly epidemics.